Assessment of Biomarkers in Acetaminophen-Induced Hepatic Toxicity by siRNA
نویسندگان
چکیده
منابع مشابه
Hepatic toxicity biomarkers
The liver is the largest internal organ in the human body and it is the main organ for the metabolism and detoxification of drugs and environmental chemicals (Klaassen, 2007). Other main functions of the liver include glucose storage and synthesis, decomposition of red blood cells, plasma protein synthesis, hormone production, and bile formation. Anatomically, the liver lies slightly below the ...
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Microsomal triglyceride transfer protein (Mtp) inhibitors represent a novel therapeutic approach to lower circulating LDL cholesterol, although therapeutic development has been hindered by the observed increase in hepatic triglycerides and liver steatosis following treatment. Here, we used small interfering RNAs (siRNA) targeting Mtp to achieve target-specific silencing to study this phenomenon...
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ژورنال
عنوان ژورنال: Biomolecules and Therapeutics
سال: 2009
ISSN: 1976-9148
DOI: 10.4062/biomolther.2009.17.4.438